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Oral tirzepatide formulations are also under development, and the oral versus injection comparison reveals meaningful differences in bioavailability and onset timing

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10.3390/pharmaceutics15041106 107

Many studies pointed to the susceptibility of mitochondrion to a great variety of compounds, and such mitochondrial damage (ultrastructural swelling, decreased mitochondrial membrane potential, etc.) may comprise early or late events in trypanocidal agent activity (Figure 2) [31]