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It functions as a soluble decoy receptor comprising the extracellular domain of the activin type IIB receptor (ActRIIB) fused to an IgG1-Fc region

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Sheng J, Liu J, Chan KH (2022) Evaluating the causal effects of gestational diabetes mellitus, heart disease, and high body mass index on maternal alzheimers disease and dementia: multivariable mendelian randomization

The possibility that aerobic glycolysis can sustain oligodendrocytes without reduced oxidative phosphorylation suggests that other stressors compound mitochondrial function to initiate oligodendrocyte death