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Endocrine Reviews, 21(5), 579-607

Review supplementation If elevated B12 results from excessive supplementation: Discontinue or reduce high-dose supplements unless medically indicated For patients receiving therapeutic B12 injections for confirmed deficiency, continue treatment as prescribedelevated levels are expected after replacement therapy and do not indicate toxicity Review with GP to ensure supplementation remains appropriate 3

This weakening in iron bonding explains the release of iron by them, which is caused by reducing agents such as GSH or ascorbic acid (contained in ferrozine analysis)

Published preclinical data in rodents suggests doses equivalent to 200mg+ in humans produce off-target effects on folate metabolism and S-adenosylmethionine (SAMe) pools

Evidence in one sentence: Both delivery systems are biologically plausible and supported by limited human biomarker or pharmacokinetic data, but neither has been proven superior for meaningful clinical outcomes