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Methodology Literature search was carried out in the PubMed database on November 3, 2021 using the queries: (TMAO) AND (atherosclerosis), (TMAO) AND (coronary artery disease), (TMAO) AND (atrial fibrillation), (TMAO) AND (heart failure), and (TMAO) AND (gut microbiota)

It is clear that ARs interactions with its protein network, as well as the type of ARE that it binds, can markedly influence the transcriptional output from DNA-bound AR, and, thus, a one-size-fits-all mechanism by which AR regulates transcription from ARE-containing genes does not apply

Animals 13(8):1350

Replication in a larger sample, especially for the nominal associations, would be worthwhile

Subsets with different preferences for BCAA metabolism have also been found in breast cancer, and further studies are needed to determine whether this is due to differences in tumor cells or the involvement of other cells in the microenvironment