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spiralis suppress macrophage-mediated inflammatory responses, reduce proinflammatory cytokine production, stimulate the differentiation of host Treg cells by activating DC, decrease the expression of IFN- and nuclear factor (NF), increase the expression of IL-4 and IL-10, change the ratio of M1/M2 phenotypic macrophages in the spleen, reduce TNF- secretion, inducing IL-10 expression [169-175]