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Moreover, the use of GST 4QN as a tag reduced fused p53 aggregation and enhanced the induction of p21 transcription and apoptosis in cells treated with 5-fluorouracil (5-FU)

The phenolic hydroxyl group of E2, particularly on the A-ring, acts as a direct free radical scavenger by donating hydrogen atoms to neutralize ROS, thereby exerting non-enzymatic antioxidant effects (118)

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171 Notably, DON showed the ability to significantly inhibit the generation and recruitment of MDSCs and to reprogram M2-like TAMs into proinflammatory TAMs, which increased tumor antigen cross-presentation to T cells and enhanced the efficacy of immune checkpoint blockade (ICB)

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