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Its worth noting that adverse effects are not common with high supplemental vitamin B12 intake, however, there is also no strong evidence to show that it has benefits in people who are not already deficient (largely due to the fact that your body only stores as much B12 as it needs and any excess will be excreted through your urine)

Van Dijk M, Van Dijk ADJ, Hsu V et al (2006) Information-driven protein-DNA docking using HADDOCK: it is a matter of flexibility

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Stay hydrated, especially during dose escalation