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2 Materials and methods 2.1 Ethical statement All animal experiments were reviewed and approved by Animal Welfare and Research Ethics Committee at Jilin University (IACUC Permit No

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Besides, high IGF-1R levels in primary tumor samples have been reported to be predictors of shorter disease-free survival, but data on the prognostic value of the IGF-1R for overall survival are contradictory (Pollak, 2012