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As the result of a critical reduction of blood flow in the brain, it causes massive loss of neurons and leads to the formation of the necrotic core and the penumbra zone [1]

NOX1 activation, which leads to the reduction of O 2 to superoxide, is completed by forming a complex with NADPH oxidase activator 1 (NOXA1), NADPH oxidase organizer 1 (NOXO1), and Rac1 GTPase [80]

1F and S1D, E) 36,37

Ansari, Lu Wang, Dakun Lai, V

McParlin C, ODonnell A, Robson SC, Beyer F, Moloney E, Bryant A, Bradley J, Muirhead CR, Nelson-Piercy C, Newbury-Birch D, Norman J, Shaw C, Simpson E, Swallow B, Yates L, Vale L (2016) Treatments for hyperemesis gravidarum and nausea and vomiting in pregnancy: a systematic review