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McGregor JE, et al

Patients report dramatic benefits, but we cannot easily separate signal from placebo, concurrent rehab changes, rest, or natural recovery

It is also less sticky and more cosmetically elegant than normal HA, so no wonder the nickname of this molecule is super hyaluronic acid.

FD has been further sub-classified into the postprandial distress syndrome (PDS) characterized by bothersome postprandial fullness or early satiation at least 3 days per week and the epigastric pain syndrome (EPS) characterized by bothersome epigastric pain or burning at least 1 day per week

How can the clinician find an appropriate balance between providing adequate pain relief while reducing the risk of developing tolerance, dependency, or abuse/misuse of opioids