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This osteogenic effect is mediated at least in part through the Transforming Growth Factor beta (TGF-) and SMAD signaling pathway

Nota bene : although fasting and starvation are metabolically distinct, here they are treated as part of a continuum (and referred to hereby only as fasting), characterized primarily by quantitative differences in metabolite levels

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Effects of Short-Term Hyperoxia on HIF-1, Its Targets, and Other Oxygen-Sensitive Transcription Factors Relevant to Aging In the process of aging, HIF-1 causes a defect in mitochondrial growth and division, which damages cellular processes dependent on energy, such as cell and tissue repair (Yuan et al., 2016)

J Biol Chem 241:17901796 Chao KF, Liu SH, Lin-Shiau SY (1996) Suppression of potassium currents by cyanide on the mouse motor nerve terminals