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and elevated 4-HNE levels found in both cartilage and synovial fluid of surgically induced canine OA models, where direct intra-articular injection of 4-HNE could replicate the cartilage destruction phenotype, accompanied by significant upregulation of MMP13, ADAMTS5, and cyclooxygenase-2 (COX2) expression (Shi et al., 2014)

OLGs that differentiate and myelinate later in life produce thinner myelin sheaths around axons and these neurons have been observed to be more susceptible to the damage in AD [32]

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