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Microglial cells trigger neuroinflammation and neurodegeneration by producing pro-inflammatory cytokines [tumor necrosis factor- (TNF-), interleukin-6 (IL-6), IL-1] and reactive oxygen species (ROS) when they are persistently activated by abnormal stimuli, neurotoxic substances, infections, or injuries [11, 12]

However, primary human keratinocytes (GM22251) exposed to PGD 2 show an increased ability to convert the androgen androstenedione into testosterone, which may be a potential therapeutic target for patients with androgenetic alopecia (AGA) [188]

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