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The pathophysiology of PD, limitations of the current treatment strategies, and the major obstacles of its therapies, including the BBB, progressive neurodegeneration, and challenges with targeting specificity are presented

Parkin, DJ-1, ubiquitin C-terminal hydrolase isozyme L1 (UCH-L1), nuclear receptor-related factor 1, and -synuclein are genes linked to either Parkinson- or Parkinson-related diseases

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Figure 8 summarizes the main points of this paper, where we claim that excessive levels of deuterium in the mitochondria due to gut dysbiosis may be the driving force that ultimately results in cardiolipin oxidation and migration to the outer membrane, following its accumulation of deuterium bound to the bis-allylic carbon atoms

Such that, the secretion of inflammatory cytokines, such as tumor necrosis factor- (TNF), would lead to neuroinflammation and migraine episodes by increasing the cellular permeability and interactions (11, 12)