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PI3K consists of four catalytic subunits (p110, , , and ) and other regulatory subunits (p101 or p85), of which and are present only in leukocytes, while the other two are widely distributed in a variety of cells

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While classical gene mutations are region-limited, epimutations often occur early in cancer development and have a genome-wide impact, boosting on the one hand the expression of cell survival genes or proto-oncogenes and deactivating on the other hand tumor suppressor genes (TSGs), DNA repair mechanisms as well as cell division brakes, thus leading to carcinogenesis ( In addition to the genetic information encoded by the primary DNA sequence, epigenetic mechanisms add a layer of regulation of the information and includes DNA methylation, histone modifications as well as regulation by non-coding RNAs ( PATHOLOGICAL ALTERATIONS OF GSTP1 METHYLATION PATTERNS DNA methylation, the addition of a methyl-group to cytosines is the most common epigenetic modification, inducing the reorganization of the gene locus and thus regulating gene expression ( In its function as a cellular caretaker, attenuation of GSTP1 expression or activity by either genetic (e.g., deletion or mutation) or epigenetic alterations may reduce cellular detoxification capacity ( Figure 2 )

Karunasena E, Larraaga MD, Simoni JS, Douglas DR, Straus DC

Similar finding which observed positive correlation between HOMA-IR and urinary-IsoP levels was reported 32