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Key findings included: Comparable anxiolytic efficacy between Selank and medazepam on standard psychometric scales (Hamilton, Zung, CGI) Selank additionally demonstrated antiasthenic and psychostimulant properties not observed with medazepam Selank subjects showed improved leu-enkephalin half-life, correlating with reduced anxiety severity Absence of amnesia, withdrawal syndrome, and dependence side effects commonly associated with benzodiazepines A separate rodent study found that combined administration of Selank and diazepam under unpredictable chronic mild stress conditions amplified anxiolytic outcomes beyond either compound administered alone, suggesting potential additive effects on GABA-A receptors[10]

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