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concomitant promoter-level increases in repressive marks (H3K27me3 gain and H3K18ac loss) were also observed in the associated methylation gene Mat1a, while MTHFR repression was mechanistically associated with miR-22 and miR-29b (84)

2015;10(2):e0116473

Competing interests The authors declare that they have no conflicts of interest related to the submitted work

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There is ongoing discussion about the potential negative consequences of prolonged activation of lysosomal pathways