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Most patients follow an active treatment phase for 9 to 18 months followed by a longer maintenance phase at reduced dosing to preserve results

The standard recommendation is 28 to 30 days when stored at 2 to 8 degrees Celsius in a refrigerator

Additionally, Clostridium sporogenes upregulate colonic IL-22 and promote Foxp3 + Treg proliferation via metabolites (indole-3-propionic acid, etc.) in a non-butyrate-dependent manner (108)

Moreover, accumulating evidence supports the potential of novel transdermal systems to enhance flavonoid delivery and therapeutic effects in preclinical AD models (Table 2)