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*Increase glutathione from 1000 mg twice per day, to 2000 mg twice per day, if methemoglobin levels rise above 5%

To validate the in vivo relevance of our cell culture observations, we subsequently examined the effects of HFD on hepatic protein-SSG adduct formation, IKK- glutathionylation, and NF-B activation

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Notably, the patients stratified as A-M and C-L displayed lipid profiles resembling those observed in the Mat1a-KO and Ldlr-KO mouse models, respectively