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10.1002/ptr.3193 52 LeeO

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In fact, LXR agonists increase ABCA1 expression and RCT 22,23 and reduce atherosclerosis in mice 24 , but their clinical development was hindered by parallel increases in plasma TG and LDL-C

Firstly, long-term exposure to air pollutants (PM2.5, NO, ozone) increases intestinal permeability, systemic inflammation, and dysbiosis [221], The UK Biobank cohort has confirmed that PM2.5 and NO significantly increase the risk of UC [222], Other studies have also revealed a correlation between PM2.5 exposure and increased rates of intestinal resection and mortality [223]