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raised ALP and gGT), typical histological features of PSC, but normal appearing bile ducts on cholangiography

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Histone acetylation is partly controlled by nuclear-cytoplasmic acetyl-CoA pools (Sivanand et al., 2017), and recent work has demonstrated that the endogenous acyl-carrier L-carnitine plays an active role in histone acetylation by shuttling acetyl units in the form of acetylcarnitine from the mitochondria and/or peroxisome and acting as a nuclear acetyl-CoA precursor (Izzo et al., 2023

The objective was to compare the baseline characteristics and outcomes, including corticosteroid response, recompensation, and survival of patients with poor KPS (Gr.A: score 50) and lastly, to assess the dynamicity of KPS and the predictors of mortality

Fan Y, Wang Y, Dan W et al