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Body aches and fatigue usually improve on their own, but certain signs indicate the need for professional evaluation: Symptoms persist beyond a week without improvement

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The dual release of both cytoplasmic dsDNA and mtDNA constitutes a strong stimulus for the cyclic GMP-AMP synthase (cGAS) recognition system, driving the activation of the stimulator of interferon genes (STING) pathway, leading to the release of type I interferons and dendritic cell maturation, which in turn promotes CD8 T cell infiltration and enhances anti-tumor immunity [268]