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In most cases, expression of the human COQ ortholog in the respective yeast coq mutant rescues efficient CoQ 6 biosynthesis and restores growth in a non-fermentable medium, highlighting the strong conservation of CoQ biosynthesis from yeast to humans

PLoS One 11 (9), e0163806

And when you try to supplement it

Atypical features, such as irritability and widespread somatic complaints (such as myalgia), are also commonly reported (36)

In these patients who would like to initiate treatment, a thorough history should be obtained to determine the opioid used, if possible, and observation may be offered until potential re-intoxication and withdrawal syndrome is seen