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When tested in normal human volunteers, it was found to exert sedative properties, but when tested in ~500 patients with various psychiatric disorders, only those with endogenous depression exhibited a remarkable improvement of clinical symptoms after 1-6 weeks of daily treatment

2APB: 2-aminoethoxydipenyl-borate APAP: acetaminophen DAMPs: damage-associated molecular patterns DMSO: dimethyl sulfoxide GSH: glutathione LDH: lactate dehydrogenase LPO: lipid peroxidation MPTP: mitochondrial membrane permeability transition pore NAC: N -acetylcysteine NK: natural killer NNT: nicotinamide nucleotide transhydrogenase P-JNK: phosphorylation of c-jun N-terminal kinase PUFAs: polyunsaturated fatty acids ROS: reactive oxygen species SEC: sinusoidal endothelial cell HJ: Conceptualization, Writingoriginal draft, Writingreview & editing

In vitro production of metabolites from pathogen The protocol for in vitro production of fungal metabolites was adapted from the method reported by Mutawila et al

It increased the anaerobic respiration of Escherichia coli EPEC ECE2348/69 , promoting its growth (Marshall et al., 2023)

This role of selenium ensures the maintenance of glutathione at its necessary levels for optimal health