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Joint and Muscle Pain Oxidative damage can cause inflammation, leading to discomfort in joints and muscles

Palamara, 1996) and herpes simplex virus-1 (HSV-I) (Palmara, 1995)

This is mechanistically distinct from proton pump inhibitor pharmacology and is part of why the peptide attracts interest as a research tool for ulcer biology and NSAID-induced gastric injury

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In the context of Fabry Disease, Gb3 accumulation also leads to the activation of toll like receptors (TLRs) particularly TLR4 (1012), which in turn stimulates the production of pro-inflammatory cytokines and chemokines, further amplifying the inflammatory response