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Further multicentre randomized studies with simpler inclusion criteria and longer follow-up than those currently available, and eventually evaluation of hard clinical outcomes (that are more closely associated with major clinical events and/or mortality than liver enzymes or insulin levels), are necessary to draw more reliable conclusions

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Activation of AMPK by upstream kinases phosphorylates target enzymes, such as acetyl-coA carboxylase (ACC), leading to inhibition of lipogenic pathways and activation of FA oxidation 22

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