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Evaluation of the in vitro permeability of copper peptides As the purpose of developing the GHK-Cu/CaT-ME system was to achieve localized delivery of copper peptides, we evaluated whether this system was effective in delivering loaded copper peptides via in vitro permeation experiments using scented pig skin [[46], [47], [48]]

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Moreover, NMN levels in muscle were negatively correlated with dermal thickness (Fig