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Loading the nanofibers with pDNA nearly doubled the transfection efficiency compared to simply mixing it into the medium, improving it from 12.1% to 23.6%

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Background: Pantothenate KinaseAssociated Neurodegeneration (PKAN) is a rare genetic disorder characterized by abnormal iron accumulation in the brain, leading to progressive motor and cognitive symptoms

In the present study, both SOD1 and GPx expressions were significantly upregulated in the animals subjected to CSD and treated with ALA (Figure 3)

Therefore, it is essential to explore the use of EGCG with both high bioavailability and beneficial effects on the body, as well as an appropriate application form meeting these requirements, such as effective delivery systems, modified EGCG, and combination with other substances