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Based on the calculations of two studies, 49,50 the approximate NAC concentration in blood should be about 1 mM during infusion of the first bag, which is enough to neutralize the potent oxidant species, suppress oxidative burst, and substantially reduce neutrophil chemotaxis and cytokine storm

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Iron deficiency remains the most common etiology, but clinicians must also consider other contributors such as chronic inflammation, vitamin B12 or folate deficiency, renal disease, and occult blood loss

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