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Pharmaceutical composition provided by the invention is with levocarnitine and ubiquinone 10 Be active ingredient, wherein levocarnitine and ubiquinone 10 Except that prototype, can also be its pharmaceutically acceptable salt or ester, or the derivant of said salt or ester.Particularly, said levocarnitine or ubiquinone 10 Pharmaceutically acceptable salt be alkali metal salt, alkali salt, perhaps be acid salt, basic salt, inner salt