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Fracture healing phases: Inflammatory phase (0-7 days) creates hematoma, recruits inflammatory cells, releases cytokines and growth factors initiating repair

doi: 10.1038/ncomms9329 91 LyonR

As a selective substrate site-targeting inhibitor of nicotinamide N-methyltransferase (NNMT) the cytosolic enzyme responsible for the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor 5-Amino-1MQ is studied as a tool compound for investigating NNMT enzyme activity, NAD salvage pathway interactions, and methylation pathway dynamics in controlled in-vitro experimental systems