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Acknowledgements This research was funded by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, NIH)

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Male factors are uniquely responsible for an estimated 30% of couples experiencing difficulty conceiving and beyond this, are a recognized contributor in approximately 50% of all cases of infertility ( in vitro fertilization (IVF) ( 2 Diagnostic andrology Traditional approaches to diagnostic andrology are grounded in the principle that a males fertility can be assessed using routine descriptive criteria of the semen profile, with emphasis being placed on sperm count, sperm morphology and sperm motility parameters ( Figure 1 )