glutathione pathway metabolites One-carbon metabolism and (GSH) synthesis and metabolism Glutathione metabolism (WP100) - Homo

These include cumulative oxidative stress, DNA damage, overactivation of the mechanistic target of rapamycin complex 1 (mTORC1) signaling, melanocyte senescence, and reduced production of pigmentation-promoting factors in the hair matrix

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Thus, the effects of PUFA (AA and AdA) to promote cell survival or induce ferroptosis may be dose dependent (Reference Tang, Zhou and Hooi66)

In addition, Nrf2 can influence the expression of genes encoding GSH-synthesizing proteins, such as SLC7A11, GCLC/GLCM, and GSS (Saha et al., 2023), thereby inhibiting peroxide production

The level of GSSG, the oxidized form of GSH, was considerably higher in the leaves and exhibited no change in the roots ( Figure 4D )