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High levels of dopamine metabolism, iron, and calcium, coupled with mitochondrial dysfunction and neuroinflammation, contribute to the excessive production of ROS in the brains of PD patients (183)

However, a previous smaller study conducted metabolomics profiling of 10 patients with DILI and compared it with chronic liver disease subgroups and hepatocellular cancer patients 45 , while another study 46 compared metabolomic changes between 13 DILI patients, 12 with autoimmune hepatitis and 24 with viral hepatitis