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It can be single heavy use activity that youve done, like in my case of carrying the very heavy bag, or more commonly its a low-level repetitive overuse, sometimes over many months until the tendon starts becoming painful

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However, the in silico screening of compound libraries was unable to provide us with a tentative lead, so we moved to an alternative strategy of screening a chemical compound library by developing two robust, yeast-based high-throughput screening assays

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