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The harmful environment created by continuous inhalation of noxious particles leads to the activation of several pattern recognition receptors (PRRs), especially Toll-like receptors (TLRs)

doi: 10.1016/j.metabol.2023.155767 7 PengYWuSLiYCraneJL

progressive staggering gait (Lower extremities are more severely affected) frequent falling titubation Dysarthria Ataxia of trunk and limb movements DTR absent Loss of proprioception Hypertrophic cardiomyopathy Diabetes mellitus associated with insulin resistance and Pancreatic -cell dysfunction

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