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Some scholars have used the synoviocyte mitochondrial gene encoding NADH dehydrogenase 1 as an entry point in order to study the mutation level of synoviocyte mtDNA in rheumatoid arthritis, and have found that the number of mutations in RA synoviocyte mtDNA is approximately twice as high as that of the OA group, and that RA fibroblasts are expressed at a mutation load of 2.3 amino acid changes per thousand base pairs, whereas in tissues, there are 2.3 changes per 2.5 amino acid changes per thousand base pairs

[DOI] [PubMed] [Google Scholar] 309.Garcia Casal MN, Rogers LM, Pasricha S-R

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The elevation in plasma KYN level in OVX animal suggested that there is increased level of systemic inflammation stress upon estrogen deprivation and that were rescued by estrogen supplementation