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LDL and its oxidized form oxLDL play a key role in endothelial damage, macrophage foam cell formation and necrosis, as well as inflammatory signaling, whereas HDL plays an atheroprotective role by driving reverse cholesterol transport and by its anti-inflammatory properties (Soppert et al., 2020)

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Phosphorylation of eIF2 by PERK in response to ER stress decreases translation of mRNA and reduces stress (Harding et al , 2003)