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Description

One hypothetical explanation for producing these -glutamyl peptides could be associated with the unique enzymatic properties of -GCS that cause a futile cycle in cases of Cys deficiencies

These changes, along with mitochondrial architectural modifications like the disappearance of cristae and swollen epithelium of the bronchi, were associated with upregulated oxidative stress and inflammation, ultimately contributing to the pathogenesis of asthma in the 12/15-LOX OE mice [40] (Figure 3)