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Therefore, we can conclude that bilirubin plays a significant role in the progression of PD by accelerating dopaminergic neuron death in the substantia nigra reticulata due to excitotoxicity induced by elevated extracellular glutamate and more studies are needed to verify this conclusion

It is an essential component in depigmentation due to its capacity to inhibit melanin synthesis

Infants of mothers on vegan or vegetarian diets are at significant risk of vitamin B12 deficiency unless the mother takes supplementary vitamin B12 (119)

75 Food and Agriculture Organization of the United Nations (2022)

Because we assume PD is a disease directly related to the brain, the gene co-expression modules that have shown high expression in other tissues are not further investigated, although they may represent another mechanism of PD