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In a placebo-controlled trial, L-citrulline, at a dose of 1.5 g/day, was found to significantly improve both erection hardness scores as well as intercourse frequency after one month of daily supplementation.[38] A 2019 systemic review and meta-analysis assessed the impact of arginine, considering 10 randomized, controlled trials that included men with mild to moderately severe ED.[39] In this review, it was found that, at a dose ranging from 1,500 to 5,000 mg/day, arginine significantly improved overall ED scores compared to placebo or no treatment

A dose-dependent response was also observed in their study [25]