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Always start with low doses and observe for any adverse reactions

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Increasing the SC dose to compensate for the lower bioavailability leads to unpredictable serum concentrations and can therefore not be recommended

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The ground-breaking finding that mice expressing dominant-negative N-cadherin, an adherent junction protein, develop spontaneous (not induced using chemicals or infections known to induce colitis in mice) inflammation in the gut epithelium further supports the key role of cell-to-cell adhesion, especially in its capacity to contribute to overall mucosal barrier function in regulating mucosal immune homeostasis