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For example, research on the efficacy of attachment-based interventions versus traditional behavioral therapies has shown that therapies focusing on building secure attachments and addressing trauma are more effective in long-term outcomes for children with DSED

02 Mechanism of Action NNMT methylates nicotinamide to produce 1-methylnicotinamide (1-MNA), consuming SAMe and depleting cellular NAD+ pools

Patient Education Anemia If you have anemia, your blood does not carry enough oxygen to the rest of your body

This increases cost without clear benefit and eliminates the ability to increase dose if initial response is insufficient

Declarations Conflict of interest The authors declare no competing interests