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The resultant oxidative stress adversely impacts cochlear homocysteine metabolism, suggesting a potential link between Vitamin B12 deficiency and demyelination of neurons in the cochlear nerve, axonal degeneration, and neuronal death

A critical element in the pathophysiology of depression is inflammation

For example, a dose of 750 mcg per shot every 3 days is equivalent to a shot of 500 mcg given every other day and equivalent to a shot of 250 mcg given daily

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