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ROS directly oxidize the glutaminase protein, altering its structure and function, and modulating metabolic pathways, including elevated mitochondrial ROS production, which further affects glutaminase activity

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Many of the experiments reviewed here rely on pharmacologic G6PD inhibition or G6PD siRNA knockdown

10.1111/acel.14184 70 HarunaY.KashiharaN.SatohM.TomitaN.NamikoshiT.SasakiT.et al (2007)