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[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Bellei B., Picardo M

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A published data meta-analysis of 18 randomized trials (15 of which had survival information) that compared chemotherapy with biochemotherapy (i.e., the same chemotherapy plus interferon alone or with IL-2) reported no impact on OS.[55][Level of evidence A1] Radiation therapy Although melanoma is a relatively radiation-resistant tumor, palliative radiation therapy may alleviate symptoms