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This improvement in fatigue lasted until the next cycle of chemotherapy (Graziano 2002)

The peptides acidic residues (glutamate at position 2 and aspartate at position 3) have been proposed to facilitate interactions with chromatin-associated proteins and transcription regulatory complexes, consistent with observed epigenetic effects documented in in-vitro model systems

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Fatigue is the most common side effect of chemotherapy, with up to 96% of patients suffering from fatigue during treatment (Iop 2004