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Beyond being a building block for proteins, cysteine has roles that include supporting the generation of antioxidants (for example, glutathione and persulfide species) 10 , metabolites (for example, H 2 S, CoA and hypotaurine) 11,12 and ironsulfur clusters for mitochondria 13

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Astrocytes sense extracellular changes through receptors such as pattern recognition receptors and cytokine receptors, detecting pathogens, A aggregates or inflammatory mediators 4,41

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

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