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While in vitro equilibrations between redox couples such as roGFP2 and GSH/GSSG require minutes or even hours to reach a thermodynamic endpoint (G = 0), enzyme-catalyzed thiol-disulfide exchange reactions usually occur very rapidly and either maintain or reach a steady state (G 0) 7,31,32,60,63,67,78,79

Notably, the increased abundance of Alistipes has been positively correlated with diseases such as intestinal inflammation, irritable bowel syndrome (Zhang et al., 2023b), depression (Parker et al., 2020), and chronic fatigue syndrome (Nagy-Szakal et al., 2017)

Nat Genet 2002;32:261-6

Well, there are various factors that contribute to the aging process