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It was also established that besides MSU crystals alone, macrophages engulfing MSU crystals and creating granulomas could further spur the generation of M1 macrophage polarization, intensifying interstitial inflammation and propagating chronic kidney disease (CKD) progression (72)

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Chem Biol Interact 369:110258 Li YJ, Chen X, Kwan TK, Loh YW, Singer J, Liu Y, Ma J, Tan J, Macia L, Mackay CR et al (2020) Dietary fiber protects against diabetic nephropathy through short-chain fatty acid-mediated activation of G protein-coupled receptors GPR43 and GPR109A

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